![]() This response starts with sensing of danger by pattern-recognition receptors on the immune competent cells and endothelium. In critical illness, the acute immune response is organized and executed by innate immunity influenced by the neuroendocrine system. critical illness) remain high despite advances in diagnostic and organ supporting possibilities in intensive care units. The mortality and morbidity in SIRS and sepsis (i.e. The host inflammatory response in SIRS and sepsis is similar and may lead to multiple organ dysfunction syndrome (MODS) and ultimately death. The systemic immune response induced by non-infectious agents is called systemic inflammatory response syndrome (SIRS) and infection-induced systemic immune response is called sepsis. ![]()
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